![]() ![]() Heterochromatin loss results in abnormal nuclear morphology, which is a hallmark of human disease ( Stephens et al., 2019a Uhler and Shivashankar, 2018). Heterochromatin is the stiff, compact, and gene-poor form of chromatin. IntroductionĬhromatin, which fills the nucleus, is a repository of information, but it is also a physical element that provides structure, mechanical rigidity, shape, and function to the nucleus. HP1α is therefore a critical chromatin-crosslinking protein that provides mechanical strength to chromosomes and the nucleus throughout the cell cycle and supports cellular functions. ![]() In mitotic chromosomes, HP1α similarly bolsters stiffness while aiding in mitotic alignment and faithful segregation. Further experiments with dimerization-deficient HP1α I165E indicate that chromatin crosslinking via HP1α dimerization is critical, while polymer simulations demonstrate the importance of chromatin-chromatin crosslinkers in mechanics. Single-nucleus micromanipulation reveals that HP1α is essential to chromatin-based mechanics and maintains nuclear morphology, separate from histone methylation. ![]() Degradation did not alter transcription, local chromatin compaction, or histone methylation, but did decrease chromatin stiffness. We used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP1α. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1α (CBX5) is unknown. Department of Physics and Astronomy, Northwestern University, United States Ĭhromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus.The Fred Hutchinson Cancer Research Center, United States.Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, United States Biology Department, University of Massachusetts Amherst, United States.Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, United States.Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology, United States. ![]()
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It was brought into the discussion by the OP who stated that he had tried it and found it to be "slow as". I then went on to say that QL reports WW748 at 35gn, 98% capacity, 3460bar as being close to (theoretical) max. The original question was about using WW748, for which QuickLOAD reports a tired load if using 28gn. On what basis do you declare that "I'd not be recommending 35gr of anything in a 6.5 Grendel"? You have some public data that can be referred to?īill, it is not my intention to pick a fight over what each of us is saying. Seems to be a suggested max load? Suggested by whom? And if 33gn is OK for a 90gn projectile, would it be unreasonable to suggest that a slightly larger powder charge might be appropriate for a lighter projectile? I did say that, as with any load development, you work up to max' with care.Īnd, as you state, 33gn seems to be a suggested max load for 90gn, so 85gn wont be far off. I don't recall anything in my previous post that suggested a load of 35gn cfe223 should be used. 33gr seems to be a suggested max load for 90gr so 85gr wont be far off.ĬFE223 work extremely well with 90-105gr in my ARC never tried it in the Grendel. Obviously too many variable but 28gr-29gr would be a very safe starting point and work your way up. Id not be recommending 35gr of anything in a 6.5 Grendel just say. You'd be getting close to that with 35gn / 3460bar / 98% case capacity.īut, as with all reloading, work up to your max with care.Įdit - QuickLOAD MV for 28gn = 2600, 35gn = 3250. No1_49er wrote:QuickLOAD figures for 748 show 28gn to be rather tired - 78% case capacity and (calculated) 1800bar pressure. ![]() |
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